| Pair Name | Decursin, TNF-related apoptosis inducing ligand | ||
| Phytochemical Name | Decursin (PubChem CID: 442126 ) | ||
| Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Decursin, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Endoplasmic reticulum stress | |||
| Gene Regulation | Up-regulation | Expression | TNFRSF10B | hsa8795 |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| Up-regulation | Activity | EIF2AK3 | hsa9451 | |
| Up-regulation | Activity | ATF4 | hsa468 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| NCI-H596 | Lung adenosquamous carcinoma | Homo sapiens (Human) | CVCL_1571 | |
| NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 | |
| Calu-1 | Lung squamous cell carcinoma | Homo sapiens (Human) | CVCL_0608 | |
| Result | ROS generation by decursin selectively activated the PERK/ATF4 axis of the endoplasmic reticulum stress signalling pathway, leading to enhanced TRAIL sensitivity in TRAIL-resistant NSCLC cell lines, partly via up-regulation of DR5. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers. Br J Pharmacol. 2016 Mar;173(6):1033-44. doi: 10.1111/bph.13408. | Click |
